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KMID : 0358419920350040498
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Korean Journal of Obstetrics and Gynecology
1992 Volume.35 No. 4 p.498 ~ p.508
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Hormone Profile in Patients with Simple Virilizing Congenital Adrenal Hyperplacia due to 21-Hydroxylase Deficiency
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Abstract
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We present here the hormone profile of three patients with simple virilizing congenital adrenal hyperplasia diagnosed by HLA typing in a family.
In order to elucidate the hormone profile, combined pituitary stimulation test and ACTH stimulation test were performed and following results were obtained.
1. ACTH, DHEAS, and aldosterone levels were significantly increased but cortisol value was in low normal limit.
Plasma progesterone and. testosterone and urinary 17-ketosteroid levels were highly increased. Baseline levels of FSH, LH, TSH and prolactin were normal.
2. While normal response of pituitary hormone was obtained in combined pituitary stimulation test, no increment of cortisol was noted between baseline and poststimulation value.
3. In ACTH stimulation test the baseline and poststimulation concentration of progesterone and 17-hydroxyprogesterone in patients with simple virilizing congenital adrenal hyperplasia were significantly higher than that of control.
4. Aldosterone level showed both elevated baseline and poststimulation concentraion suggesting normal response to ACTH stimulation.
In conclusion ACTH stimulation test is highly useful in diagnosing congenital adrenal hyperplasia and activity of 21-hydroxylase in zona glomerulosa was normal in simple virilizing congenital adrenal hyperplasia.
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